Ownership Profile

Shareholder Breakdown
Shareholder Holders Values ($) % O/S Shares
Institution 137 300 72.18 102,418,953
Mutual Fund 127 89 23.80 33,769,078
Institutional Shareholder Rotation
Shareholder Holders Values Change ($) % O/S Shares Change
Buyers 71 22.71 5.21 7,391,313
Sellers 42 -18.26 4.40 -6,246,688
Net -- 4.46 0.81 1,144,625
Institutional Shareholder Concentration
Shareholder Values ($) % O/S Shares
Top 10 Inst. 254 61.53 87,302,435
Top 20 Inst. 276.87 66.75 94,706,609
Top 50 Inst. 293.45 70.69 100,305,202
Total Inst. 293.45 70.69 100,305,202
Institutional Shareholder Style
Shareholder Holders Values ($) % O/S Shares
Index 18 56 12.81 18,176,743
AggresGr 2 1 0.23 325,460
CoreGrowth 17 3 0.72 1,026,456
Growth 4 0 0.09 124,120
IncomeValue 1 1 0.23 332,050
Yield 2 0 0.02 22,000
BrokerDealer 18 7 1.52 2,157,074
GARP 13 51 11.59 16,448,781
HedgeFund 19 22 4.95 7,019,636
SectorSpecific 1 5 1.07 1,520,126
Specialty 1 0 0.01 12,173
CoreValue 12 76 17.46 24,769,242
DeepValue 4 2 0.36 507,981
Momentum 1 0 0.00 4,288
Top Holders: Institutional Investor
Holder Shares Held % O/S Shares Change Filing Date
Aurigene Discovery Technologies, Ltd. 27,328,464 19.26 10,208,333 09/07/2016
First Eagle Investment Management, L.L.C. 24,008,672 16.92 0 12/31/2016
Fidelity Management & Research Company 14,569,979 10.27 -2,270,439 12/31/2016
BlackRock Institutional Trust Company, N.A. 8,703,291 6.13 776,591 12/31/2016
The Vanguard Group, Inc. 4,523,357 3.19 151,629 12/31/2016
Cormorant Asset Management LLC 2,410,900 1.70 0 12/31/2016
State Street Global Advisors (US) 1,663,980 1.17 86,308 12/31/2016
Polar Capital LLP 1,520,126 1.07 1,520,126 12/31/2016
McNab (James R Jr) 1,379,688 0.97 0 01/31/2016
Millennium Management LLC 1,193,978 0.84 1,193,978 12/31/2016
Northern Trust Investments, Inc. 1,179,216 0.83 -1,293 12/31/2016
Adage Capital Management, L.P. 1,035,000 0.73 600,000 12/31/2016
TIAA Global Asset Management 914,889 0.64 102,806 12/31/2016
RBC Capital Markets Wealth Management 849,796 0.60 9,930 12/31/2016
Geode Capital Management, L.L.C. 848,453 0.60 50,187 12/31/2016
D. E. Shaw & Co., L.P. 706,070 0.50 213,369 12/31/2016
Columbia Threadneedle Investments (US) 504,447 0.36 -2,614 12/31/2016
Oppenheim Asset Management Services S.à r.l. 471,866 0.33 -67,835 12/31/2016
BlackRock Investment Management, LLC 452,808 0.32 -1,788 12/31/2016
Marshall Wace LLP 441,629 0.31 -210,277 12/31/2016
Medical Strategy GmbH 415,246 0.29 -95,774 11/30/2016
Renaissance Technologies LLC 361,100 0.25 217,800 12/31/2016
TFS Capital LLC 337,840 0.24 325,301 12/31/2016
BNY Mellon Asset Management 332,050 0.23 14,291 12/31/2016
Morgan Stanley & Co. LLC 324,803 0.23 301,093 12/31/2016
Bridgeway Capital Management, Inc. 275,460 0.19 -83,225 12/31/2016
Vident Investment Advisory, LLC 247,867 0.17 247,867 12/31/2016
California State Teachers Retirement System 229,679 0.16 -6,500 12/31/2016
California Public Employees' Retirement System 219,400 0.15 0 12/31/2016
Passeri (Daniel R) 211,798 0.15 12,900 01/31/2016
PanAgora Asset Management Inc. 191,972 0.14 -4,682 12/31/2016
Susquehanna Financial Group, LLLP 189,231 0.13 189,231 12/31/2016
Focused Wealth Management, Inc. 187,250 0.13 -1,100 12/31/2016
Telemetry Investments, L.L.C. 185,000 0.13 -65,000 12/31/2016
Fidelity Institutional Asset Management 168,400 0.12 168,400 12/31/2016
Charles Schwab Investment Management, Inc. 158,654 0.11 0 12/31/2016
J.P. Morgan Securities LLC 154,485 0.11 154,485 12/31/2016
Assenagon Asset Management S.A. 154,231 0.11 3,886 02/28/2017
Weiss Multi-Strategy Advisers LLC 124,000 0.09 0 12/31/2016
Goldman Sachs & Company, Inc. 121,504 0.09 33,150 12/31/2016
Citi Investment Research (US) 120,958 0.09 90,909 12/31/2016
Rhumbline Advisers Ltd. Partnership 120,165 0.08 -21,351 12/31/2016
Janney Montgomery Scott LLC 111,300 0.08 3,800 12/31/2016
ProFund Advisors LLC 110,778 0.08 18,113 12/31/2016
Gray (Michael P) 107,304 0.08 0 01/31/2016
New York State Common Retirement Fund 101,500 0.07 0 12/31/2016
Wells Fargo Bank, N.A. 91,054 0.06 59,739 12/31/2016
Morgan Stanley Wealth Management 86,651 0.06 -3 12/31/2016
Metropolitan Life Insurance Co. (US) 82,518 0.06 5,585 12/31/2016
Northern Trust Global Investments 76,395 0.05 5,743 12/31/2016

Ownership data is provided by Thomson Reuters, a third party service, and Curis, Inc. does not maintain or provide information directly to this service.