Curis is a biotechnology company focused on the development and commercialization of innovative and effective drug candidates for the treatment of human cancers. The Company currently has two drug candidates in development:
> CUDC-907, an orally available small molecule inhibitor of HDAC and PI3K enzymes being investigated in a Phase 2 clinical trial in patients with MYC-altered diffuse large B-cell lymphoma and in a Phase 1 trial in patients with MYC-altered solid tumors.
> CA-170, an orally-available small molecule antagonist of PD-L1 and VISTA immune checkpoints being investigated in a Phase 1 clinical trial in patients with advanced solid tumors or lymphomas.
Curis is engaged in a broad collaboration with Aurigene for discovery and development of drug candidates in the area of immuno-oncology. As part of this collaboration, Curis has the exclusive license to CA-170, and has also selected a second program that focuses on small molecule antagonists of PD-1 and TIM3 pathways, including compounds that target PD-L1/TIM3 immune checkpoints. Curis has also licensed the exclusive rights to orally-available small molecule inhibitors of the IRAK4 kinase, including the development candidate CA-4948 from Aurigene.
The Company's collaborators, F. Hoffmann-La Roche Ltd, or Roche, and Genentech Inc., or Genentech, a member of the Roche Group, are commercializing Erivedge® (vismodegib) for the treatment of patients with advanced basal cell carcinoma, or BCC. Roche and Genentech are continuing Erivedge®’s clinical development in less severe forms of BCC as well as in other diseases including idiopathic pulmonary fibrosis, or IPF, and myelofibrosis.
Oct 11, 2016
Oct 11, 2016
Curis Expands Oncology Pipeline with an Oral Small Molecule PD-L1/TIM-3 Immune Checkpoint Antagonist
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